Partial Inhibition of Sarcoplasmic Reticulum Ca Release Evokes Long-Lasting Ca Release Events in Ventricular Myocytes: Role of Luminal Ca in Termination of Ca Release
نویسندگان
چکیده
منابع مشابه
Sarcoplasmic reticulum Ca release in intact ventricular myocytes.
Sarcoplasmic reticulum (SR) Ca release in intact ventricular myocytes is the major source of Ca which activates cardiac contraction (although Ca influx makes a non-negligible contribution in most species). The fundamental events of SR Ca release are known as Ca sparks. The twitch Ca transient is composed of approximately 10,000 Ca sparks occurring in a given cell, and they are synchronized by t...
متن کاملLuminal Ca Controls Termination and Refractory Behavior of Ca -Induced Ca Release in Cardiac Myocytes
Despite extensive research, the mechanisms responsible for the graded nature and early termination of Ca -induced Ca release (CICR) from the sarcoplasmic reticulum (SR) in cardiac muscle remain poorly understood. Suggested mechanisms include cytosolic Ca -dependent inactivation/adaptation and luminal Ca -dependent deactivtion of the SR Ca release channels/ryanodine receptors (RyRs). To explore ...
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Shkryl VM, Maxwell JT, Domeier TL, Blatter LA. Refractoriness of sarcoplasmic reticulum Ca release determines Ca alternans in atrial myocytes. Am J Physiol Heart Circ Physiol 302: H2310–H2320, 2012. First published March 30, 2012; doi:10.1152/ajpheart.00079.2012.—Cardiac alternans is a recognized risk factor for cardiac arrhythmia and sudden cardiac death. At the cellular level, Ca alternans ap...
متن کاملMeasuring local gradients of intramitochondrial [Ca(2+)] in cardiac myocytes during sarcoplasmic reticulum Ca(2+) release.
RATIONALE Mitochondrial [Ca(2+)] ([Ca(2+)](mito)) regulates mitochondrial energy production, provides transient Ca(2+) buffering under stress, and can be involved in cell death. Mitochondria are near the sarcoplasmic reticulum (SR) in cardiac myocytes, and evidence for crosstalk exists. However, quantitative measurements of [Ca(2+)](mito) are limited, and spatial [Ca(2+)](mito) gradients have n...
متن کاملSarcoplasmic Reticulum Luminal [Ca
The role that sarcoplasmic reticulum (SR) luminal Ca 2+ concentration plays in regulating ryanodine receptors (RyRs) is considered to be very important in process of cardiac excitation-contraction coupling. Here we developed a multi-scale mathematical model by coupling a two-dimensional spatio-temporal Ca 2+ reaction-diffusion model with an action potential model of the ventricular myocyte. The...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2008
ISSN: 0006-3495
DOI: 10.1529/biophysj.107.114694